4wvm

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'''Unreleased structure'''
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==Stonustoxin structure==
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<StructureSection load='4wvm' size='340' side='right' caption='[[4wvm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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The entry 4wvm is ON HOLD until May 03 2017
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synanceia_horrida Synanceia horrida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WVM FirstGlance]. <br>
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Authors: Ellisdon, A.M., Panjikar, S., Whisstock, J.C., McGowan, S.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvm OCA], [http://pdbe.org/4wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wvm RCSB], [http://www.ebi.ac.uk/pdbsum/4wvm PDBsum]</span></td></tr>
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</table>
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Description:
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/STXA_SYNHO STXA_SYNHO]] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref> [[http://www.uniprot.org/uniprot/STXB_SYNHO STXB_SYNHO]] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Synanceia horrida]]
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[[Category: Ellisdon, A M]]
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[[Category: McGowan, S]]
[[Category: Panjikar, S]]
[[Category: Panjikar, S]]
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[[Category: Ellisdon, A.M]]
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[[Category: Whisstock, J C]]
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[[Category: Whisstock, J.C]]
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[[Category: Cytolysin]]
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[[Category: Mcgowan, S]]
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[[Category: Macpf cdc]]
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[[Category: Membrane attack complex]]
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[[Category: Perforin cholesterol dependent]]
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[[Category: Pry]]
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[[Category: Spry]]
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[[Category: Thioredoxin focal adhesion targeting]]
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[[Category: Toxin]]
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[[Category: Venom]]

Revision as of 16:15, 2 December 2015

Stonustoxin structure

4wvm, resolution 3.10Å

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