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5d7p
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of human Sirt2 in complex with ADPR and EX-243== |
| - | + | <StructureSection load='5d7p' size='340' side='right' caption='[[5d7p]], [[Resolution|resolution]] 1.76Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5d7p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=OCZ:(1S)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-+CARBOXAMIDE'>OCZ</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7p OCA], [http://pdbe.org/5d7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7p RCSB], [http://www.ebi.ac.uk/pdbsum/5d7p PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Einsle, O]] | ||
[[Category: Gerhardt, S]] | [[Category: Gerhardt, S]] | ||
[[Category: Jung, M]] | [[Category: Jung, M]] | ||
| - | [[Category: | + | [[Category: Rumpf, T]] |
| + | [[Category: Deacylase]] | ||
| + | [[Category: Human sirtuin 2]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor complex]] | ||
Revision as of 16:17, 2 December 2015
Crystal structure of human Sirt2 in complex with ADPR and EX-243
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