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Autophagy-related protein
From Proteopedia
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<StructureSection load='3vh3' size='340' side='right' caption='Yeast Atg7 C terminal (grey) complex with Atg8 (green) and Zn+2 ion (grey) (PDB code [[3vh3]])' scene=''> | <StructureSection load='3vh3' size='340' side='right' caption='Yeast Atg7 C terminal (grey) complex with Atg8 (green) and Zn+2 ion (grey) (PDB code [[3vh3]])' scene=''> | ||
| - | '''Autophagy-related proteins''' (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis. So far 34 Atgs have been identified in yeast. <br /> | + | '''Autophagy-related proteins''' (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis.<ref>PMID:26382870</ref> So far 34 Atgs have been identified in yeast. <br /> |
*'''Atg1, 6, 14''' are involved in the formation of the phagophore. <br /> | *'''Atg1, 6, 14''' are involved in the formation of the phagophore. <br /> | ||
*'''Atg3''' catalyzes the conjugation of Atg8 and phosphatidylethanolamine. This conjugation is essential for autophagosome formation. <br /> | *'''Atg3''' catalyzes the conjugation of Atg8 and phosphatidylethanolamine. This conjugation is essential for autophagosome formation. <br /> | ||
Revision as of 10:55, 3 December 2015
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3D Structures of autophagy-related protein
Updated on 03-December-2015
References
- ↑ Shibutani ST, Saitoh T, Nowag H, Munz C, Yoshimori T. Autophagy and autophagy-related proteins in the immune system. Nat Immunol. 2015 Sep 18;16(10):1014-24. doi: 10.1038/ni.3273. PMID:26382870 doi:http://dx.doi.org/10.1038/ni.3273
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