Anthrax edema factor
From Proteopedia
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<StructureSection load='1pk0' size='340' side='right' caption='EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and adenine diphosphate derivative, Ca+2 (light green) and Yt+3 (green) ions (PDB code [[1pk0]]).' scene=''> | <StructureSection load='1pk0' size='340' side='right' caption='EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and adenine diphosphate derivative, Ca+2 (light green) and Yt+3 (green) ions (PDB code [[1pk0]]).' scene=''> | ||
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== Function == | == Function == | ||
| - | '''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one. | + | '''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> |
== Disease == | == Disease == | ||
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== References == | == References == | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:14, 3 December 2015
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3D structures of anthrax edema factor
Updated on 03-December-2015
1lvc – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP
1pk0 - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP
1s26 - EF adenylate cyclase domain C terminal + calmodulin + methylene-ATP
1sk6 - EF adenylate cyclase domain C terminal + calmodulin + pyrophosphate + cAMP
1xfu - EF (mutant) + calmodulin
1xfv - EF + calmodulin + deoxy-ATP
1xfw - EF + calmodulin + cAMP
1xfx, 1xfy, 1xfz - EF + calmodulin
References
- ↑ Abrami L, Reig N, van der Goot FG. Anthrax toxin: the long and winding road that leads to the kill. Trends Microbiol. 2005 Feb;13(2):72-8. PMID:15680766 doi:http://dx.doi.org/10.1016/j.tim.2004.12.004
