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Actinin
From Proteopedia
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== Function == | == Function == | ||
| - | [[Actinin]] attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:<br /> | + | [[Actinin]] attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells.<ref>PMID:18488141</ref> Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:<br /> |
* '''ACTN1''' encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.<br /> | * '''ACTN1''' encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.<br /> | ||
* '''ACTN2''' encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br /> | * '''ACTN2''' encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br /> | ||
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**[[3aaa]] – cbA + myotrophin | **[[3aaa]] – cbA + myotrophin | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:04, 3 December 2015
Contents |
Function
Actinin attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells.[1] Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:
- ACTN1 encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.
- ACTN2 encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see Group:MUZIC:actinin2.
- ACTN3 encodes aA3 which anchors actin at the muscle Z-disk.
- ACTN4 encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis.
Structural highlights
Actinin contain four 3-helix bundles which are called spectrin repeat (SR). SR are found in proteins belonging to the cytoskeletal structure like spectrin and dystrophin.
3D Structures of Actinin
Updated on 03-December-2015
References
- ↑ Sjoblom B, Salmazo A, Djinovic-Carugo K. Alpha-actinin structure and regulation. Cell Mol Life Sci. 2008 Sep;65(17):2688-701. doi: 10.1007/s00018-008-8080-8. PMID:18488141 doi:http://dx.doi.org/10.1007/s00018-008-8080-8
