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CD47
From Proteopedia
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<StructureSection load='2jjs' size='350' side='right' scene='53/538855/Cv/1' caption='Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions [[2jjs]]'> | <StructureSection load='2jjs' size='350' side='right' scene='53/538855/Cv/1' caption='Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions [[2jjs]]'> | ||
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== Function == | == Function == | ||
Revision as of 09:23, 6 December 2015
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Contents |
3D Structures of CD47
Updated on 06-December-2015
2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate
References
- ↑ Chao MP, Weissman IL, Majeti R. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol. 2012 Apr;24(2):225-32. doi: 10.1016/j.coi.2012.01.010. Epub, 2012 Feb 4. PMID:22310103 doi:http://dx.doi.org/10.1016/j.coi.2012.01.010
- ↑ Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508 doi:10.1016/j.molcel.2008.05.026
