Centromere protein
From Proteopedia
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'''Centromere proteins''' (CENP) X,S,W,T make up the kinetochore structure on chromatids where the spindle fibers attach during cell division to pull the chromatids apart. <br /> | '''Centromere proteins''' (CENP) X,S,W,T make up the kinetochore structure on chromatids where the spindle fibers attach during cell division to pull the chromatids apart. <br /> | ||
• '''CENP-X''' is a component of the Fanconi Anemia core. <br /> | • '''CENP-X''' is a component of the Fanconi Anemia core. <br /> | ||
| - | • '''CENP-B''' facilitates centromere formation.<br /> | + | • '''CENP-B''' facilitates centromere formation.<ref>PMID:11726497</ref><br /> |
| - | • '''CENP-A''' is a component of modified nucleosome replacing hitone H3.<br /> | + | • '''CENP-A''' is a component of modified nucleosome replacing hitone H3.<ref>PMID:20739937</ref><br /> |
| - | • '''CENP-E''' is a motor protein involved inchromosome movement.<br /> | + | • '''CENP-E''' is a motor protein involved inchromosome movement.<ref>PMID:15159587</ref><br /> |
| - | • '''CENP-M''' is involved in the kinetochore assembly.<br /> | + | • '''CENP-M''' is involved in the kinetochore assembly.<ref>PMID:25006165</ref><br /> |
* '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle. | * '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle. | ||
Revision as of 09:40, 6 December 2015
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3D structures of centromere protein
Updated on 06-December-2015
References
- ↑ Tanaka Y, Nureki O, Kurumizaka H, Fukai S, Kawaguchi S, Ikuta M, Iwahara J, Okazaki T, Yokoyama S. Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA. EMBO J. 2001 Dec 3;20(23):6612-8. PMID:11726497 doi:10.1093/emboj/20.23.6612
- ↑ Sekulic N, Bassett EA, Rogers DJ, Black BE. The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. Nature. 2010 Aug 25. PMID:20739937 doi:10.1038/nature09323
- ↑ Garcia-Saez I, Blot D, Kahn R, Kozielski F. Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure. Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1158-60. Epub 2004, May 21. PMID:15159587 doi:http://dx.doi.org/10.1107/S0907444904009564
- ↑ Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A. The pseudo GTPase CENP-M drives human kinetochore assembly. Elife (Cambridge). 2014 Jul 8;3:e02978. doi: 10.7554/eLife.02978. PMID:25006165
