Ceruloplasmin
From Proteopedia
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<StructureSection load='1kcw' size='350' side='right' caption='Glycosylated human ceruloplasmin complex with Cu+2 ions (orange) and O atoms (red) (PDB entry [[1kcw]])' scene=''> | <StructureSection load='1kcw' size='350' side='right' caption='Glycosylated human ceruloplasmin complex with Cu+2 ions (orange) and O atoms (red) (PDB entry [[1kcw]])' scene=''> | ||
| + | __TOC__ | ||
| + | == Function == | ||
'''Ceruloplasmin''' (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism.<ref>PMID:12055353</ref> | '''Ceruloplasmin''' (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism.<ref>PMID:12055353</ref> | ||
| - | + | == Relevance == | |
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| + | CP testing is used in diagnosis of the rare inherited disorder - Wilson disease. | ||
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| + | == Disease == | ||
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| + | CP mutation causes the autosomal recessive disorder - Aceruloplasminemia which results in accumulation of iron in the brain. | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 11:20, 6 December 2015
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3D structures of ceruloplasmin
Updated on 06-December-2015
1kcw, 2j5w, 4enz – hCP - human
4ejx – hCP + myeloperoxidase
References
- ↑ Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr. 2002;22:439-58. Epub 2002 Apr 4. PMID:12055353 doi:http://dx.doi.org/10.1146/annurev.nutr.22.012502.114457
