Aminomutase

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<StructureSection load='2ohy' size='340' side='right' caption='Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code [[2ohy]])' scene='71/715468/Cv/1'>
<StructureSection load='2ohy' size='340' side='right' caption='Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code [[2ohy]])' scene='71/715468/Cv/1'>
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'''Aminomutases''' catalyze the exchange of hydrogen atom and an amine substituent on a neighboring carbon atom.<ref>PMID:17516659</ref>
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'''Aminomutases''' catalyze the exchange of hydrogen atom and an amine substituent on a neighboring carbon atom.<ref name="Ad">PMID:17516659</ref>
*'''Phenylalanine aminomutase''' (PAM) catalyzes the reversible conversion of L-phenylalanine to ammonia and trans-cinnamic acid. Ala-Ser-Gly derived chromophore is a cofactor.
*'''Phenylalanine aminomutase''' (PAM) catalyzes the reversible conversion of L-phenylalanine to ammonia and trans-cinnamic acid. Ala-Ser-Gly derived chromophore is a cofactor.
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== Structural highlights ==
== Structural highlights ==
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TAM active site residues facilitate the deprotonation/reprotonation reaction. <scene name='71/715468/Cv/2'>The active site</scene> includes residues from both monomers in Tyrosine aminomutase (PDB code [[2ohy]]).<ref>PMID:17516659</ref>
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TAM active site residues facilitate the deprotonation/reprotonation reaction. <scene name='71/715468/Cv/2'>The active site</scene> includes residues from both monomers in Tyrosine aminomutase (PDB code [[2ohy]]).<ref name="Ad">PMID:17516659</ref>
</StructureSection>
</StructureSection>

Revision as of 09:16, 7 December 2015

Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code 2ohy)

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3D structures of aminomutase

Updated on 07-December-2015

References

  1. ↑ 1.0 1.1 Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 2007 Jun 19;46(24):7205-14. Epub 2007 May 22. PMID:17516659 doi:10.1021/bi7003685

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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