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Cholesterol esterase

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{{STRUCTURE_1llf| PDB=1llf | SIZE=350| SCENE= |right|CAPTION=Cholesterol esterase dimer complex with bile acid [[1llf]] }}
{{STRUCTURE_1llf| PDB=1llf | SIZE=350| SCENE= |right|CAPTION=Cholesterol esterase dimer complex with bile acid [[1llf]] }}
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== Function ==
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'''Cholesterol esterase''' (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides. Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.
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'''Cholesterol esterase''' (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.
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== Disease ==
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Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.
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== Structural highlights ==
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ChoE ligand-binding tunnel is ca. 30 A long and has the catalytic triad Ser-His-Glu at the opening and hydrophobic residues lining the bottom cup.<ref>PMID:12499539</ref>
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</StructureSection>
==3D structures of cholesterol esterase==
==3D structures of cholesterol esterase==
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**[[1aql]] – bChoE + taurocholate
**[[1aql]] – bChoE + taurocholate
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:56, 7 December 2015

Template:STRUCTURE 1llf

Contents

Function

Cholesterol esterase (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.

Disease

Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

Structural highlights

ChoE ligand-binding tunnel is ca. 30 A long and has the catalytic triad Ser-His-Glu at the opening and hydrophobic residues lining the bottom cup.[1] </StructureSection>

3D structures of cholesterol esterase

Updated on 07-December-2015

References

  1. ↑ Pletnev V, Addlagatta A, Wawrzak Z, Duax W. Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):50-6. Epub 2002 Dec, 19. PMID:12499539

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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