Cholesterol oxidase

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== Function ==
== Function ==
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'''Cholesterol oxidase''' (COX) catalyzes the conversion of cholesterol and molecular oxygen to Colest-4-en-3-one and hydrogen peroxide. COX uses FAD as a cofactor. '''COX I''' binds FAD non-covalently whereas '''COX II''' binds FAD covalently.<ref>PMID:12843408</ref>
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'''Cholesterol oxidase''' (COX) catalyzes the conversion of cholesterol and molecular oxygen to Colest-4-en-3-one and hydrogen peroxide. COX uses FAD as a cofactor. '''COX I''' binds FAD non-covalently whereas '''COX II''' binds FAD covalently.<ref>PMID:20102741</ref>
== Relevance ==
== Relevance ==

Revision as of 11:43, 7 December 2015

Cholesterol oxidase complex with steroid substrate (PDB entry 1coy)

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3D structure of cholesterol oxidase

Updated on 07-December-2015


References

  1. Sagermann M, Ohtaki A, Newton K, Doukyu N. Structural characterization of the organic solvent-stable cholesterol oxidase from Chromobacterium sp. DS-1. J Struct Biol. 2010 Apr;170(1):32-40. Epub 2010 Jan 25. PMID:20102741 doi:10.1016/j.jsb.2010.01.012

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Michal Harel, Alexander Berchansky

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