Chymotrypsin Inhibitor
From Proteopedia
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| + | <StructureSection load='1tm1' size='350' side='right' caption='Chymotrypsin Inhibitor 2 complex with subtilisin (PDB entry [[1tm1]])' scene=''> | ||
| - | + | == Function == | |
[[Chymotrypsin Inhibitor|Chymotrypsin Inhibitors]] (CI) are serine proteinase inhibitors of chymotrypsin. They are classified by numbers: CI-1<ref>PMID:7922044</ref>, CI-2<ref>PMID:3828302</ref>, CI-3<ref>PMID:10531477</ref>. | [[Chymotrypsin Inhibitor|Chymotrypsin Inhibitors]] (CI) are serine proteinase inhibitors of chymotrypsin. They are classified by numbers: CI-1<ref>PMID:7922044</ref>, CI-2<ref>PMID:3828302</ref>, CI-3<ref>PMID:10531477</ref>. | ||
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| + | == Structural highlights == | ||
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| + | CI inhibition is achieved by the insertion of a loop into the serine protease active site. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Chymotrypsin Inhibitor == | == 3D Structures of Chymotrypsin Inhibitor == | ||
Revision as of 09:41, 8 December 2015
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3D Structures of Chymotrypsin Inhibitor
Updated on 08-December-2015
References
- ↑ Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure. 1994 Jul 15;2(7):679-89. PMID:7922044
- ↑ McPhalen CA, James MN. Crystal and molecular structure of the serine proteinase inhibitor CI-2 from barley seeds. Biochemistry. 1987 Jan 13;26(1):261-9. PMID:3828302
- ↑ Ravichandran S, Sen U, Chakrabarti C, Dattagupta JK. Cryocrystallography of a Kunitz-type serine protease inhibitor: the 90 K structure of winged bean chymotrypsin inhibitor (WCI) at 2.13 A resolution. Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1814-21. PMID:10531477
