Cocaine esterase
From Proteopedia
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<StructureSection load='1l7q' size='350' side='right' caption='Cocaine esterase complex with reaction product benzoic acid (PDB entry [[1l7q]])' scene=''> | <StructureSection load='1l7q' size='350' side='right' caption='Cocaine esterase complex with reaction product benzoic acid (PDB entry [[1l7q]])' scene=''> | ||
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to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
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== Function == | == Function == | ||
| - | '''Cocaine esterase''' (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid | + | '''Cocaine esterase''' (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. <ref>PMID:11742345</ref> |
== Relevance == | == Relevance == | ||
CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse. | CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse. | ||
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| + | == Structural highlights == | ||
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| + | CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of cocaine esterase== | ==3D structures of cocaine esterase== | ||
Revision as of 12:01, 8 December 2015
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3D structures of cocaine esterase
Updated on 08-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
