Aromatic amine dehydrogenase

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== Function ==
== Function ==
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'''Aromatic amine dehydrogenase''' (AADH) catalyzes the conversion of primary aromatic amine and acceptor to aldehyde and reduced acceptor. The acceptor co-factor is tryptophan tryptophylquinone (TTQ).
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'''Aromatic amine dehydrogenase''' (AADH) catalyzes the conversion of primary aromatic amine and acceptor to aldehyde and reduced acceptor. The acceptor co-factor is tryptophan tryptophylquinone (TTQ).<ref>PMID:8188594</ref>
== Structural highlights ==
== Structural highlights ==

Revision as of 12:36, 8 December 2015

Structure of aromatic amine dehydrogenase large subunit (cyan and green) and small subunit (magenta and salmon) with cofactor TTQ complex with phenylacetaldehyde (PDB code 2i0s).

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3D structures of aromatic amine dehydrogenase

Updated on 08-December-2015

2ah1 – AfAADH – Alcaligenes faecalis
2i0r, 2iup, 2iur, 2iuv, 2iot, 2oiz – AfAADH + TTQ derivative
2agl – AfAADH + TTQ derivative + phenylhydrazine
2agw, 2iuq – AfAADH + TTQ derivative + tryptamine
2agx, 2agy – AfAADH + TTQ derivative + indol ethanimine
2ojy – AfAADH + TTQ derivative + indol acetamide
2agz, 2ah0 – AfAADH + TTQ derivative + indol aminoethanol
2ok6 – AfAADH + TTQ derivative + formyl amino tryptophan
2hxc – AfAADH + TTQ + benzylamine
2hj4, 2hjb – AfAADH + TTQ derivative + benzylamine derivative
2i0s – AfAADH + TTQ + phenylacetaldehyde
2i0t – AfAADH + TTQ + phenyl alcohol
2ok4 – AfAADH + TTQ derivative + phenylacetaldehyde
2q7q – AfAADH + TTQ derivative + phenyl methanamine
2hkm – AfAADH + TTQ derivative + phenyl ethyl amine
2hkr – AfAADH + TTQ derivative + methoxyphenyl ethanamide + methoxyphenyl acetamide
2h3x, 2h47, 2iaa – AfAADH + TTQ derivative + azurin


References

  1. ↑ Govindaraj S, Eisenstein E, Jones LH, Sanders-Loehr J, Chistoserdov AY, Davidson VL, Edwards SL. Aromatic amine dehydrogenase, a second tryptophan tryptophylquinone enzyme. J Bacteriol. 1994 May;176(10):2922-9. PMID:8188594
  2. ↑ Roujeinikova A, Hothi P, Masgrau L, Sutcliffe MJ, Scrutton NS, Leys D. New insights into the reductive half-reaction mechanism of aromatic amine dehydrogenase revealed by reaction with carbinolamine substrates. J Biol Chem. 2007 Aug 17;282(33):23766-77. Epub 2007 May 1. PMID:17475620 doi:10.1074/jbc.M700677200

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Alexander Berchansky, Michal Harel

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