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Arrestin

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== Function ==
== Function ==
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'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.
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'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.<ref>PMID:10219246</ref>
== Structural highlights ==
== Structural highlights ==
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Revision as of 13:06, 8 December 2015

Bovine arrestin-2 complex with Ba+2 ions (PDB code 2wtr)

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3D Structures of arrestin

Updated on 08-December-2015

References

  1. Hirsch JA, Schubert C, Gurevich VV, Sigler PB. The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation. Cell. 1999 Apr 16;97(2):257-69. PMID:10219246

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Michal Harel, Alexander Berchansky

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