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5c3t

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'''Unreleased structure'''
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==PD-1 binding domain from human PD-L1==
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<StructureSection load='5c3t' size='340' side='right' caption='[[5c3t]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c3t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3T FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqk|4zqk]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3t OCA], [http://pdbe.org/5c3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3t RCSB], [http://www.ebi.ac.uk/pdbsum/5c3t PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small cell lung cancer, and other types of cancer. Small-molecule drugs interfering with this pathway are highly awaited, but their development is hindered by insufficient structural information. This study reveals the molecular details of the human PD-1/PD-L1 interaction based on an X-ray structure of the complex. First, it is shown that the ligand binding to human PD-1 is associated with significant plasticity within the receptor. Second, a detailed molecular map of the interaction surface is provided, allowing definition of the regions within both interacting partners that may likely be targeted by small molecules.
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The entry 5c3t is ON HOLD until Paper Publication
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Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.,Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187<ref>PMID:26602187</ref>
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Authors: Zak, K.M., Dubin, G., Holak, T.A.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description:
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<div class="pdbe-citations 5c3t" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Holak, T.A]]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Dubin, G]]
[[Category: Dubin, G]]
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[[Category: Zak, K.M]]
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[[Category: Holak, T A]]
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[[Category: Zak, K M]]
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[[Category: Immune system]]
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[[Category: Immunology]]
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[[Category: Ligand]]
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[[Category: Pd1/pdl1 axis]]

Revision as of 07:18, 9 December 2015

PD-1 binding domain from human PD-L1

5c3t, resolution 1.80Å

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