1ao7
From Proteopedia
(Difference between revisions)
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|PDB= 1ao7 |SIZE=350|CAPTION= <scene name='initialview01'>1ao7</scene>, resolution 2.6Å | |PDB= 1ao7 |SIZE=350|CAPTION= <scene name='initialview01'>1ao7</scene>, resolution 2.6Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=EMC:ETHYL MERCURY ION'>EMC</scene> | + | |LIGAND= <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= HLA-A 0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= HLA-A 0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ao7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ao7 OCA], [http://www.ebi.ac.uk/pdbsum/1ao7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ao7 RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions. | Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions. | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Ankylosing spondylitis, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Stevens-Johnson syndrome, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Utz, U.]] | [[Category: Utz, U.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
| - | [[Category: EMC]] | ||
[[Category: class i mhc]] | [[Category: class i mhc]] | ||
[[Category: complex (mhc/viral peptide/receptor]] | [[Category: complex (mhc/viral peptide/receptor]] | ||
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[[Category: viral peptide]] | [[Category: viral peptide]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:44:18 2008'' |
Revision as of 15:44, 30 March 2008
| |||||||
| , resolution 2.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | HLA-A 0201 (Homo sapiens), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - (Homo sapiens), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA (Homo sapiens), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201
Overview
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
About this Structure
1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.
Reference
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788
Page seeded by OCA on Sun Mar 30 18:44:18 2008
