5cay
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor== |
| + | <StructureSection load='5cay' size='340' side='right' caption='[[5cay]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cay]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CAY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cay OCA], [http://pdbe.org/5cay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cay RCSB], [http://www.ebi.ac.uk/pdbsum/5cay PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | HIV-2 is a non-pandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term non-progression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30-40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0 A structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence. | ||
| - | + | Structure of an HIV-2 gp120 in complex with CD4.,Davenport YW, West AP Jr, Bjorkman PJ J Virol. 2015 Nov 25. pii: JVI.02678-15. PMID:26608312<ref>PMID:26608312</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5cay" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: Davenport, Y | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bjorkman, P J]] | ||
| + | [[Category: Davenport, Y W]] | ||
| + | [[Category: Cd4]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Gp120]] | ||
| + | [[Category: Hiv-2]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 13:41, 9 December 2015
Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor
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