4yo2

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'''Unreleased structure'''
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==Structure of E2F8, an atypical member of E2F family of transcription factors==
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<StructureSection load='4yo2' size='340' side='right' caption='[[4yo2]], [[Resolution|resolution]] 3.07&Aring;' scene=''>
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The entry 4yo2 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4yo2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YO2 FirstGlance]. <br>
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Authors: Morgunova, E., Yin, Y., Jolma, A., Dave, K., Schmierer, B., Popov, A., Eremina, N., Nilsson, L., Taipale, J.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yo2 OCA], [http://pdbe.org/4yo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yo2 RCSB], [http://www.ebi.ac.uk/pdbsum/4yo2 PDBsum]</span></td></tr>
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</table>
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Description: Structure of E2F8, an atypical member of E2F family of transcription factors
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/E2F8_HUMAN E2F8_HUMAN]] Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.<ref>PMID:15897886</ref> <ref>PMID:16179649</ref> <ref>PMID:18202719</ref> <ref>PMID:22903062</ref>
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[[Category: Nilsson, L]]
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== References ==
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[[Category: Schmierer, B]]
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<references/>
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[[Category: Popov, A]]
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__TOC__
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[[Category: Yin, Y]]
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</StructureSection>
[[Category: Dave, K]]
[[Category: Dave, K]]
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[[Category: Eremina, N]]
[[Category: Jolma, A]]
[[Category: Jolma, A]]
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[[Category: Taipale, J]]
 
[[Category: Morgunova, E]]
[[Category: Morgunova, E]]
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[[Category: Eremina, N]]
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[[Category: Nilsson, L]]
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[[Category: Popov, A]]
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[[Category: Schmierer, B]]
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[[Category: Taipale, J]]
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[[Category: Yin, Y]]
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[[Category: Dna-complex]]
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[[Category: E2f family]]
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[[Category: Fusion protein]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]

Revision as of 13:47, 9 December 2015

Structure of E2F8, an atypical member of E2F family of transcription factors

4yo2, resolution 3.07Å

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