1aqo
From Proteopedia
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|PDB= 1aqo |SIZE=350|CAPTION= <scene name='initialview01'>1aqo</scene> | |PDB= 1aqo |SIZE=350|CAPTION= <scene name='initialview01'>1aqo</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqo OCA], [http://www.ebi.ac.uk/pdbsum/1aqo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aqo RCSB]</span> | ||
}} | }} | ||
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[[Category: translational regulation]] | [[Category: translational regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:45:44 2008'' |
Revision as of 15:45, 30 March 2008
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES
Overview
The iron responsive element (IRE) is a approximately 30 nucleotide RNA hairpin that is located in the 5' untranslated region of all ferritin mRNAs and in the 3' untranslated region of all transferrin receptor mRNAs. The IREs are bound by two related IRE-binding proteins (IRPs) which help control intracellular levels of iron by regulating the expression of both ferritin and transferrin receptor genes. Multi-dimensional NMR and computational approaches were used to study the structure and dynamics of the IRE RNA in solution. The NMR data are consistent with formation of A-form helical stem regions, a one-base internal bulge and a Watson-Crick C.G base-pair between the first and fifth nucleotides in the loop. A superposition of refined structures indicates that the conserved C in the internal bulge, and three residues in the six-nucleotide hairpin loop are quite dynamic in this RNA. The structural roles of the stems, the loop and the bulge in the function of the IRE RNA and in possible interactions with the iron regulatory protein are discussed.
About this Structure
1AQO is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins., Addess KJ, Basilion JP, Klausner RD, Rouault TA, Pardi A, J Mol Biol. 1997 Nov 21;274(1):72-83. PMID:9398517
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