User:Elisha Lacey/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Bromodomain testis specific== | ==Bromodomain testis specific== | ||
<StructureSection load='1stp' size='340' side='right' caption='Bromodomain testis specific as functional dimer=''> | <StructureSection load='1stp' size='340' side='right' caption='Bromodomain testis specific as functional dimer=''> | ||
| - | Bromodomain testis specific also known as known as CT9 and RING3-like protein and belongs to the bromodomain extra terminal (BET) family. | + | Bromodomain testis specific (BRDT) also known as known as CT9 and RING3-like protein and belongs to the bromodomain extra terminal (BET) family. BRDT is expressed in pachytene and diplotene spermatocytes and round spermatids. |
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
Bromodomain testis specific is a monomer that is only fully functional as a dimer. BRDT is a transcriptional regulator for gene expression during spermatogenesis. | Bromodomain testis specific is a monomer that is only fully functional as a dimer. BRDT is a transcriptional regulator for gene expression during spermatogenesis. | ||
| - | == | + | == BRDT and fertility == |
| - | + | Loss of one of the bromodomains leads to decrease spermatogenesis and defective sperm. If both bromodomains are knocked out it leads to loss of fertility. | |
== Relevance == | == Relevance == | ||
| - | + | Male contraception has been eluding scientists for years and is a desired area to prevent unplanned pregnancies. In studies of an anti-cancer drug triazolotheinodiaepine known as JQ1 that inhibits BRD4 in cancer pathogenesis. In experiments in mice it is seen, due to structural similarities, JQ1 blocks the production of sperm in testes. The binding of JQ1 in the acetyl-lysine pocket prevents recognition of acetylated histone H4KAC4. | |
| - | == Structural highlights == | + | == Structural highlights == |
| - | + | The functional unit for BRDT is two bromodomain motifs, each monomer is composed of 4 anti-parallel alpha helixes. | |
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 02:10, 10 December 2015
Bromodomain testis specific
| |||||||||||
References
Berkovits B, Wolgemuth D. The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background. PMC. 2011 Dec 15: 360 (2):358-368.
Barda S, Yogev L, Paz G, et al. BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility. Andrology. 2014 May 28; 2(4): 641-647.
Zdrojewicz Z, Konieczyn R, Papier P, Szten F.Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception. ACEM. 2015 Feb 23; 24(4):705-714.
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
