5'-deoxy-5'-methylthioadenosine phosphorylase
From Proteopedia
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== Function == | == Function == | ||
| - | '''5’-deoxy-5’-methylthioadenosine phosphorylase''' (MTAP) catalyzes the reversible phosphorolysis of <scene name='59/595220/Cv/2'>5’-deoxy-5’-methylthioadenosine (MTA)</scene> to adenine and 5-methylthio-D-ribose-1-phosphate. <scene name='59/595220/Cv/4'>Click here to see active site</scene> (PDB code [[1cg6]]). | + | '''5’-deoxy-5’-methylthioadenosine phosphorylase''' (MTAP) catalyzes the reversible phosphorolysis of <scene name='59/595220/Cv/2'>5’-deoxy-5’-methylthioadenosine (MTA)</scene> to adenine and 5-methylthio-D-ribose-1-phosphate. <scene name='59/595220/Cv/4'>Click here to see active site</scene> (PDB code [[1cg6]]). MTAP is part of the polyamine metabolism. This reaction is the principle source of adenine in human cells. MTAP catalyzes the first step in the methionine salvage pathway.<ref>PMID:10404592</ref> |
== Disease == | == Disease == | ||
Revision as of 11:15, 13 December 2015
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3D structures of 5’-deoxy-5’-methylthioadenosine phosphorylase
Updated on 13-December-2015
References
- ↑ Appleby TC, Erion MD, Ealick SE. The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis. Structure. 1999 Jun 15;7(6):629-41. PMID:10404592
