Complement C3
From Proteopedia
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== Function == | == Function == | ||
| - | '''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663. | + | '''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref> |
== Disease == | == Disease == | ||
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| + | A mutation in CC3 cause the progressive kidney disease: dense deposit disease. Other mutations are associated with recurrent bacterial infections. | ||
== Relevance == | == Relevance == | ||
| - | + | Low levels of CC3 in the blood are associated with some kidney diseases. | |
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</StructureSection> | </StructureSection> | ||
Revision as of 07:27, 14 December 2015
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3D structures of complement C3
Updated on 14-December-2015
