Concanavalin
From Proteopedia
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<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene=''> | <StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene=''> | ||
| + | __TOC__ | ||
| + | == Function == | ||
| - | '''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces. | + | '''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref> |
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| + | == Relevance == | ||
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| + | ConA has therapeutic effect on liver cancer. | ||
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| + | == Structural highlights == | ||
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| + | ConA contains a metal - Mn+2 and Ca+2 - binding site as well as a sugar binding site. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Concanavalin A == | == 3D Structures of Concanavalin A == | ||
Revision as of 10:31, 14 December 2015
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3D Structures of Concanavalin A
Updated on 14-December-2015
References
- ↑ Loris R, Hamelryck T, Bouckaert J, Wyns L. Legume lectin structure. Biochim Biophys Acta. 1998 Mar 3;1383(1):9-36. PMID:9546043
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Michal Harel, Alexander Berchansky, Eran Hodis, Jaime Prilusky
