CREB-binding protein

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'''CREB-binding protein''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.
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== Function ==
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'''CREB-binding protein''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>
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== Disease ==
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Mutations in CBP cause Rubinstein-Taybi syndrome.<ref>PMID:7630403</ref>
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== Structural highlights ==
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CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.
== 3D Structures of CREB-binding protein ==
== 3D Structures of CREB-binding protein ==
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**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
}}
}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:38, 15 December 2015

Image:1kbh.png
Crystal structure of CREB-binding protein (green) complex with nuclear receptor coactivator (grey) 1kbh

Template:STRUCTURE 3p1c











Contents

Function

CREB-binding protein (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. [1]

Disease

Mutations in CBP cause Rubinstein-Taybi syndrome.[2]

Structural highlights

CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.

3D Structures of CREB-binding protein

Updated on 15-December-2015

References

  1. ↑ Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9. PMID:8413673 doi:http://dx.doi.org/10.1038/365855a0
  2. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ, et al.. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995 Jul 27;376(6538):348-51. PMID:7630403 doi:http://dx.doi.org/10.1038/376348a0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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