Cruzain
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | |||
<StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain complex with methylketone inhibitor (PDB entry [[1me3]])' scene=''> | <StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain complex with methylketone inhibitor (PDB entry [[1me3]])' scene=''> | ||
| - | '''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID: | + | '''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:7707373</ref> |
</StructureSection> | </StructureSection> | ||
==3D structures of cruzain== | ==3D structures of cruzain== | ||
Revision as of 11:05, 15 December 2015
| |||||||||||
3D structures of cruzain
Updated on 15-December-2015
1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ
References
- ↑ McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24;247(2):251-9. PMID:7707373 doi:http://dx.doi.org/S0022-2836(84)70137-9
