Cullin
From Proteopedia
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<StructureSection load='1ldj' size='340' side='right' caption='Human cullin-1 (grey) complex with ring box protein 1 (green) and Zn+2 ion (grey) (PDB code [[1ldj]])' scene=''> | <StructureSection load='1ldj' size='340' side='right' caption='Human cullin-1 (grey) complex with ring box protein 1 (green) and Zn+2 ion (grey) (PDB code [[1ldj]])' scene=''> | ||
| - | '''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases. They combine with ring box proteins (RBX) to form the CRL complex. The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction. Cullin-1 to 7 are part of the multi-subunit ubiquitin complex. Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br /> | + | '''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases. They combine with ring box proteins (RBX) to form the CRL complex.<ref>PMID:15688063</ref> The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction. Cullin-1 to 7 are part of the multi-subunit ubiquitin complex. Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br /> |
*'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<br /> | *'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<br /> | ||
*'''Cullin-2''' is part of the ECS (Elongin-cullin-SOCS-box) complex.<br /> | *'''Cullin-2''' is part of the ECS (Elongin-cullin-SOCS-box) complex.<br /> | ||
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*'''Cullin-4A and 4B''' regulate various processes like DNA repair, chromatin remodeling and mitotic cell cycle.<br /> | *'''Cullin-4A and 4B''' regulate various processes like DNA repair, chromatin remodeling and mitotic cell cycle.<br /> | ||
*'''Cullin-5''' inhibits cellular proliferation.<br /> | *'''Cullin-5''' inhibits cellular proliferation.<br /> | ||
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| - | == Function == | ||
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| - | == Disease == | ||
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| - | == Relevance == | ||
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| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:47, 15 December 2015
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3D Structures of cullin
Updated on 15-December-2015
References
- ↑ Petroski MD, Deshaies RJ. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20. PMID:15688063 doi:http://dx.doi.org/10.1038/nrm1547
