1atl
From Proteopedia
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|PDB= 1atl |SIZE=350|CAPTION= <scene name='initialview01'>1atl</scene>, resolution 1.8Å | |PDB= 1atl |SIZE=350|CAPTION= <scene name='initialview01'>1atl</scene>, resolution 1.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CH3:METHYL+GROUP'>CH3</scene>, <scene name='pdbligand=SLE:2-(THIOMETHYLENE)-4-METHYLPENTANOIC+ACID'>SLE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1atl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1atl OCA], [http://www.ebi.ac.uk/pdbsum/1atl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1atl RCSB]</span> | ||
}} | }} | ||
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[[Category: Njoroge, F G.]] | [[Category: Njoroge, F G.]] | ||
[[Category: Zhang, D.]] | [[Category: Zhang, D.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: CH3]] | ||
| - | [[Category: ZN]] | ||
[[Category: metalloendopeptidase]] | [[Category: metalloendopeptidase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:47:12 2008'' |
Revision as of 15:47, 30 March 2008
| |||||||
| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Activity: | Atrolysin C, with EC number 3.4.24.42 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (FORM-D)
Overview
The structure of the metalloproteinase and hemorrhagic toxin atrolysin C form d (EC 3.4.24.42), from the venom of the western diamondback rattlesnake Crotalus atrox, has been determined to atomic resolution by x-ray crystallographic methods. This study illuminates the nature of inhibitor binding with natural (< Glu-Asn-Trp, where < Glu is pyroglutamic acid) and synthetic (SCH 47890) ligands. The primary specificity pocket is exceptionally deep; the nature of inhibitor and productive substrate binding is discussed. Insights gained from the study of these complexes facilitate the design of potential drugs to treat diseases where matrix metalloproteinases have been implicated, e.g., arthritis and tumor metastasis.
About this Structure
1ATL is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.
Reference
Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d)., Zhang D, Botos I, Gomis-Ruth FX, Doll R, Blood C, Njoroge FG, Fox JW, Bode W, Meyer EF, Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8447-51. PMID:8078901
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