CXC chemokine receptor
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code [[3oe0]])' scene='43/438522/Cv/1' > |
CXC chemokine receptors bind to cytokines of the CXC chemokine family. [[CXC chemokine receptor type 4]] '''(CXCR4)''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). The CXRC4 is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:020929726</ref>. This image based on [[3oe0]]. '''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the CXC motif. | CXC chemokine receptors bind to cytokines of the CXC chemokine family. [[CXC chemokine receptor type 4]] '''(CXCR4)''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). The CXRC4 is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:020929726</ref>. This image based on [[3oe0]]. '''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the CXC motif. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:33, 16 December 2015
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3D Structures of CXCR4
Updated on 16-December-2015
- ↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396
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