CXC chemokine receptor
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code [[3oe0]])' scene='43/438522/Cv/1' > | <StructureSection load='' size='350' side='right' caption='Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code [[3oe0]])' scene='43/438522/Cv/1' > | ||
| - | CXC chemokine receptors bind to cytokines of the CXC chemokine family. '''CXCR4''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:020929726</ref> | + | CXC chemokine receptors bind to cytokines of the CXC chemokine family. '''CXCR4''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:020929726</ref>. '''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the CXC motif. |
</StructureSection> | </StructureSection> | ||
__NOTOC__ | __NOTOC__ | ||
Revision as of 08:39, 16 December 2015
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3D Structures of CXCR4
Updated on 16-December-2015
References
- ↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396
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