Cyclic GMP-AMP synthase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='4o67' size='340' side='right' caption='Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code [[4o67]]). ' scene=''> |
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== Function == | == Function == | ||
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Mice lacking CGAS are more vulnerable to lethal infection by DNA virus. | Mice lacking CGAS are more vulnerable to lethal infection by DNA virus. | ||
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| + | == Structural highlights == | ||
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| + | The 2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:16, 16 December 2015
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3D structures of cyclic GMP-AMP synthase
Updated on 16-December-2015
References
- ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
