1au6
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1au6 |SIZE=350|CAPTION= <scene name='initialview01'>1au6</scene> | |PDB= 1au6 |SIZE=350|CAPTION= <scene name='initialview01'>1au6</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=BPT:BIS(TRANS-PLATINUM ETHYLENEDIAMINE DIAMINE CHLORO)COMPLEX'>BPT</scene> | + | |LIGAND= <scene name='pdbligand=BPT:BIS(TRANS-PLATINUM+ETHYLENEDIAMINE+DIAMINE+CHLORO)COMPLEX'>BPT</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1au6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au6 OCA], [http://www.ebi.ac.uk/pdbsum/1au6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1au6 RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Wang, A H.J.]] | [[Category: Wang, A H.J.]] | ||
[[Category: Yang, D.]] | [[Category: Yang, D.]] | ||
| - | + | [[Category: bisplatinum compound (1,1/t,t)]] | |
| - | + | ||
| - | [[Category: bisplatinum compound (1]] | + | |
[[Category: deoxyribonucleic acid]] | [[Category: deoxyribonucleic acid]] | ||
[[Category: dna]] | [[Category: dna]] | ||
[[Category: dumbbell structure]] | [[Category: dumbbell structure]] | ||
[[Category: interstrand crosslink]] | [[Category: interstrand crosslink]] | ||
| - | [[Category: t)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:47:37 2008'' |
Revision as of 15:47, 30 March 2008
| |||||||
| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
About this Structure
1AU6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126
Page seeded by OCA on Sun Mar 30 18:47:37 2008
