We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Cyclin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | <StructureSection load='3blh' size='350' side='right' caption='Cyclin A3 (PDB entry [[1vin]])' scene=''> | ||
| + | == Function == | ||
| - | + | '''Cyclin''' (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs, '''CYCA''' is active in the S phase, '''CYCD''' regulate the transition from G1 to S.<ref>PMID:12910258</ref> See also [[Intrinsically Disordered Protein]]. | |
| - | + | ||
| - | '''Cyclin''' (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that | + | |
| + | == Structural highlights == | ||
| + | All cyclins have an all-α helix fold and share an identical ca. 100 residue domain called 'cyclin box' which binds CDK. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:09, 16 December 2015
| |||||||||||
3D Structures of Cyclin
Updated on 16-December-2015
References
- ↑ Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003 Aug 11;22(33):5208-19. PMID:12910258 doi:http://dx.doi.org/10.1038/sj.onc.1206558
