Cyclohydrolase

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== Function ==
== Function ==
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• '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis<br />
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• '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis<ref>PMID:7663943</ref> <br />
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• '''GTP cyclohydrolase II''' catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism. <br />
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• '''GTP cyclohydrolase II''' catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.<ref>PMID:16115872</ref> <br />
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• '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis<br />
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• '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis<ref>PMID:17407260</ref> <br />
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• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<br />
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• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<ref>PMID:23013430</ref> <br />
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* '''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.
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* '''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.<ref>PMID:10828945</ref>
== Disease ==
== Disease ==
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Mutations in GTP cyclohydrolase I are associated with malignant phenylketonuria, hyperphenylalaninemia and DOPA-responsive dystonia.
== Relevance ==
== Relevance ==

Revision as of 11:40, 16 December 2015

Structure of GTP cyclohydrolase I pentamer complex with 8-oxo-GTP (stick model) and Zn+2 ion (grey) (PDB code 1wuq).

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3D structures of cyclohydrolase

Updated on 16-December-2015

References

  1. ↑ Nar H, Huber R, Meining W, Schmid C, Weinkauf S, Bacher A. Atomic structure of GTP cyclohydrolase I. Structure. 1995 May 15;3(5):459-66. PMID:7663943
  2. ↑ Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK. GTP cyclohydrolase II structure and mechanism. J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:16115872 doi:10.1074/jbc.M507725200
  3. ↑ Kang YN, Tran A, White RH, Ealick SE. A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase. Biochemistry. 2007 May 1;46(17):5050-62. Epub 2007 Apr 4. PMID:17407260 doi:http://dx.doi.org/10.1021/bi061637j
  4. ↑ Upadhyay V, Demmer U, Warkentin E, Moll J, Shima S, Ermler U. Structure and catalytic mechanism of N(5),N(10)-methenyl-tetrahydromethanopterin cyclohydrolase. Biochemistry. 2012 Oct 23;51(42):8435-43. doi: 10.1021/bi300777k. Epub 2012 Oct, 8. PMID:23013430 doi:http://dx.doi.org/10.1021/bi300777k
  5. ↑ Schmidt A, Wu H, MacKenzie RE, Chen VJ, Bewly JR, Ray JE, Toth JE, Cygler M. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35. PMID:10828945

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Michal Harel, Alexander Berchansky

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