Journal:JBIC:33
From Proteopedia
(Difference between revisions)

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Parameters characterizing the overall and internal mobility of Zn-bound | Parameters characterizing the overall and internal mobility of Zn-bound | ||
Zmp1 within the Lipari-Szabo model (see static image below). The ‘’Model-Free’’ formalism parameterizes | Zmp1 within the Lipari-Szabo model (see static image below). The ‘’Model-Free’’ formalism parameterizes | ||
- | intramolecular dynamics in terms of an overall tumbling correlation time | + | intramolecular dynamics in terms of an overall tumbling correlation time t<sub>c</sub>, generalized |
order parameters S<sup>2</sup> | order parameters S<sup>2</sup> | ||
, and of the correlation time for internal motions, which can be | , and of the correlation time for internal motions, which can be | ||
- | considered as arising from two components, one describing faster ( | + | considered as arising from two components, one describing faster (t<sub>f</sub>) and one slower (t<sub>s</sub>) |
- | motions (collectively called | + | motions (collectively called t<sub>e</sub>), but always faster than te<sub>c</sub>. Motions on intermediate time |
- | scales (ms to | + | scales (ms to t<sub>s</sub> ), characteristic of exchange processes (R<sub>ex</sub>), may also contribute to |
transverse relaxation through the fluctuation of the chemical environment of a nucleus. | transverse relaxation through the fluctuation of the chemical environment of a nucleus. | ||
The line reported in the graph of Rex rapresents the average value. The secondary | The line reported in the graph of Rex rapresents the average value. The secondary | ||
structure elements are reported at the top. Residues which experience local mobility (R<sub>ex</sub> | structure elements are reported at the top. Residues which experience local mobility (R<sub>ex</sub> | ||
- | or | + | or t<sub>e</sub>) are also mapped into the Zmp1 structure in orange and blue respectively. The |
radius of the atom bonds is proportional to the magnitude of these values. Zinc is | radius of the atom bonds is proportional to the magnitude of these values. Zinc is | ||
represented as orange sphere, binding residues as sticks. | represented as orange sphere, binding residues as sticks. |
Revision as of 12:48, 16 December 2015
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- ↑ REF
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