2n7n
From Proteopedia
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| - | ''' | + | ==NMR structure of Peptide PG-989 in DPC micelles== |
| + | <StructureSection load='2n7n' size='340' side='right' caption='[[2n7n]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n7n]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7N FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n7o|2n7o]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7n OCA], [http://pdbe.org/2n7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7n RCSB], [http://www.ebi.ac.uk/pdbsum/2n7n PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor. | ||
| - | + | Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352<ref>PMID:26599352</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2n7n" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brancaccio, D]] | ||
| + | [[Category: Carotenuto, A]] | ||
| + | [[Category: Chai, M]] | ||
[[Category: Grieco, P]] | [[Category: Grieco, P]] | ||
| - | [[Category: Brancaccio, D]] | ||
[[Category: Hruby, V]] | [[Category: Hruby, V]] | ||
| + | [[Category: Merlino, F]] | ||
| + | [[Category: Novellino, E]] | ||
[[Category: Yousif, A]] | [[Category: Yousif, A]] | ||
| - | [[Category: | + | [[Category: De novo protein]] |
| - | + | ||
| - | + | ||
Revision as of 13:49, 16 December 2015
NMR structure of Peptide PG-989 in DPC micelles
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