We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
4x9a
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Nucleoprotein-nucleozin complex== |
| - | + | <StructureSection load='4x9a' size='340' side='right' caption='[[4x9a]], [[Resolution|resolution]] 2.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4x9a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X9A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NUZ:[4-(2-CHLORO-4-NITROPHENYL)PIPERAZIN-1-YL](5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)METHANONE'>NUZ</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x9a OCA], [http://pdbe.org/4x9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x9a RCSB], [http://www.ebi.ac.uk/pdbsum/4x9a PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0]] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hao, Q]] | [[Category: Hao, Q]] | ||
[[Category: Pang, B]] | [[Category: Pang, B]] | ||
| + | [[Category: Influenza np]] | ||
| + | [[Category: Nucleozin]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 13:53, 16 December 2015
Nucleoprotein-nucleozin complex
| |||||||||||
