1b1v
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b1v OCA], [http://www.ebi.ac.uk/pdbsum/1b1v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b1v RCSB]</span> | ||
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[[Category: plasmatocyte-spreading]] | [[Category: plasmatocyte-spreading]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:51:55 2008'' |
Revision as of 15:51, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS
Overview
The structure of the recently identified plasmatocyte spreading peptide from the moth Pseudoplusia includens (PSP1) has been determined by NMR spectroscopy. This novel insect cytokine consists of 23 amino acid residues and a single disulfide bond. Torsion angle dynamics calculations utilizing a total of 337 distance constraints yielded an ensemble of 30 structures with an average backbone root mean square deviation for residues 7-22 of 0.18 A from the mean structure. The structure consists of a disordered N-terminal region and a well defined core that is stabilized by numerous hydrophobic interactions and a short beta-hairpin. Structural comparisons confirm that PSP1 adopts an epidermal growth factor (EGF)-like fold with close similarity to the C-terminal subdomain of EGF-like module 5 of human thrombomodulin. The combination of the three-dimensional structure of PSP1 and the extensive literature on EGF-receptor interactions should accelerate the process of identifying the specific residues responsible for receptor binding activity of this family of immunoregulatory peptides.
About this Structure
1B1V is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1 from Pseudoplusia includens., Volkman BF, Anderson ME, Clark KD, Hayakawa Y, Strand MR, Markley JL, J Biol Chem. 1999 Feb 19;274(8):4493-6. PMID:9988679
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