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1b2d

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|PDB= 1b2d |SIZE=350|CAPTION= <scene name='initialview01'>1b2d</scene>, resolution 1.70&Aring;
|PDB= 1b2d |SIZE=350|CAPTION= <scene name='initialview01'>1b2d</scene>, resolution 1.70&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1b17|1B17]], [[1b18|1B18]], [[1b19|1B19]], [[1b2a|1B2A]], [[1b2b|1B2B]], [[1b2c|1B2C]], [[1b2d|1B2D]], [[1b2e|1B2E]], [[1b2f|1B2F]], [[1b2g|1B2G]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b2d OCA], [http://www.ebi.ac.uk/pdbsum/1b2d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b2d RCSB]</span>
}}
}}
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[[Category: Caspar, D L.D.]]
[[Category: Caspar, D L.D.]]
[[Category: Diao, J S.]]
[[Category: Diao, J S.]]
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[[Category: SO4]]
 
[[Category: hormone]]
[[Category: hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:05:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:52:07 2008''

Revision as of 15:52, 30 March 2008

Image:1b2d.gif


PDB ID 1b2d

Drag the structure with the mouse to rotate
, resolution 1.70Å
Ligands:
Related: 1B17, 1B18, 1B19, 1B2A, 1B2B, 1B2C, 1B2D, 1B2E, 1B2F, 1B2G


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES)


Overview

Structures of porcine insulin crystals soaked in 1 M sodium sulfate at pH 5.00, 5.53, 5.80, 6.00, 6.16, 6.26, 6.35, 6.50, 6.98 and 9.00 have been determined at between 1.7 and 1.9 A resolution. GluB13 exhibits a single conformation at pH </= 5.80, two conformations between pH 6.00 and 6.98 and a single conformation at pH 9.00. Between pH 6.00 and 6.98, the conformation of GluB13 switches from one rotamer to another rotamer. Between pH 6.16 and 6.26, PheB1 undergoes a significant conformational change. By pH 9.00 many residues have undergone relatively large shifts and HisB10 exhibits a double conformation. As a result of the pH increase, the occupancy of the sulfate ion decreases from a maximum of 1.00 at pH 5.00 to a minimum of 0.46 at pH 6.50. Comparison of the structures, the observed and calculated structure factors and map correlation coefficients indicate that the porcine insulin structure changes gradually as a function of pH.

About this Structure

1B2D is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Crystallographic titration of cubic insulin crystals: pH affects GluB13 switching and sulfate binding., Diao J, Acta Crystallogr D Biol Crystallogr. 2003 Apr;59(Pt 4):670-6. Epub 2003, Mar 25. PMID:12657786

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