Cyclophilin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_2x25| PDB=2x25 | SIZE=400| SCENE= |right|CAPTION=human Cyclophilin-A with acetyllysine, [[2x25]] }} | ||
| - | [[Cyclophilin]] (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. | ||
| + | <StructureSection load='2x25' size='350' side='right' caption='Human Cyclophilin-A with acetyllysine (PDB entry [[2x25]])' scene=''> | ||
| + | |||
| + | [[Cyclophilin]] (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. <ref>PMID:11742345</ref> | ||
| + | </StructureSection> | ||
== 3D Structures of Cyclophilin == | == 3D Structures of Cyclophilin == | ||
| Line 134: | Line 136: | ||
**[[4dz2]], [[4dz3]] – BpPin1 (mutant) + FK506<BR /> | **[[4dz2]], [[4dz3]] – BpPin1 (mutant) + FK506<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:15, 17 December 2015
| |||||||||||
3D Structures of Cyclophilin
Updated on 17-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
