Cyclophilin
From Proteopedia
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<StructureSection load='2x25' size='350' side='right' caption='Human Cyclophilin-A with acetyllysine (PDB entry [[2x25]])' scene=''> | <StructureSection load='2x25' size='350' side='right' caption='Human Cyclophilin-A with acetyllysine (PDB entry [[2x25]])' scene=''> | ||
| - | [[Cyclophilin]] (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. <ref>PMID:11742345</ref> | + | [[Cyclophilin]] (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The '''Cyp-A/cyclosporin A''' complex inhibits organ rejection. '''Cyp-D''' is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. <ref>PMID:11742345</ref> |
</StructureSection> | </StructureSection> | ||
== 3D Structures of Cyclophilin == | == 3D Structures of Cyclophilin == | ||
Revision as of 08:17, 17 December 2015
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3D Structures of Cyclophilin
Updated on 17-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
