Cytochrome c oxidase
From Proteopedia
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<StructureSection load='2occ' size='350' side='right' caption='Bovine cytochrome c oxidase. Homodimer with 13 subunits (PDB entry [[2occ]])' scene=''> | <StructureSection load='2occ' size='350' side='right' caption='Bovine cytochrome c oxidase. Homodimer with 13 subunits (PDB entry [[2occ]])' scene=''> | ||
| + | __TOC__ | ||
| + | == Function == | ||
'''Cytochrome c oxidase''' (CcO) is a transmembrane protein complex found in bacteria and mitochondria. CcO is the last enzyme in the electron transport chain. <ref>PMID:7652554</ref> | '''Cytochrome c oxidase''' (CcO) is a transmembrane protein complex found in bacteria and mitochondria. CcO is the last enzyme in the electron transport chain. <ref>PMID:7652554</ref> | ||
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| + | == Disease == | ||
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| + | CcO deficiency is a genetic condition which affects muscle weakness, muscle tone upto severe brain dysfunction in severe cases. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 11:04, 17 December 2015
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3D Structures of Cytochrome c oxidase
Updated on 17-December-2015
References
- ↑ Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A. Science. 1995 Aug 25;269(5227):1069-74. PMID:7652554
- ↑ Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T. Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044
