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Stepler sandbox STAT3
From Proteopedia
(Difference between revisions)
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== Structure == | == Structure == | ||
| - | The STAT3 protein is composed of several <scene name='71/714950/Stat3_helix_turn_helix/1'>Helix Turn Helix</scene> structures and its quaternary structure consists of two STAT3 proteins <scene name='71/714950/Stat3_dimer/1'>dimerized</scene> with themselves. <ref>PMID:9671298</ref> | + | The STAT3 protein is composed of several <scene name='71/714950/Stat3_helix_turn_helix/1'>Helix Turn Helix</scene> structures and its quaternary structure consists of two STAT3 proteins <scene name='71/714950/Stat3_dimer/1'>dimerized</scene> with themselves. <ref>PMID:9671298</ref> |
== Regulation == | == Regulation == | ||
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== DNA-Protein Interactions == | == DNA-Protein Interactions == | ||
| - | The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein interacts with DNA</scene> by binding to the major groove of | + | The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein dimer interacts with DNA</scene> by wrapping around it. <scene name='71/714950/Dna-binding_domain/4'>Stat3 interacts with DNA</scene> by binding to the major groove of it. STAT3 (along with other STAT family members) bind to specific DNA sequences. <ref>PMID:11050435</ref> STAT3 has a binding domain with sequences like TTN(5-6)AA. <scene name='71/714950/Dna-binding_domain/3'>This stretch</scene> is then what interacts with the STAT3 protein. As shown in the scene, the DNA is bound by the protein in its major groove. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 12:40, 18 December 2015
STAT3
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References
- ↑ Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502. PMID:11050435
- ↑ Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298 doi:10.1038/28101
- ↑ Yu Z, Kone BC. The STAT3 DNA-binding domain mediates interaction with NF-kappaB p65 and inducible nitric oxide synthase transrepression in mesangial cells. J Am Soc Nephrol. 2004 Mar;15(3):585-91. PMID:14978160
- ↑ Sakaguchi M, Oka M, Iwasaki T, Fukami Y, Nishigori C. Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells. J Invest Dermatol. 2012 Jul;132(7):1877-85. doi: 10.1038/jid.2012.45. Epub 2012, Mar 15. PMID:22418867 doi:http://dx.doi.org/10.1038/jid.2012.45
- ↑ Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502. PMID:11050435
