C-X-C motif chemokine

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{{STRUCTURE_1qg7|right| PDB=1qg7 | SCENE= |CAPTION=CXCL12α dimer complex with sulfate, [[1qg7]] }}
{{STRUCTURE_1qg7|right| PDB=1qg7 | SCENE= |CAPTION=CXCL12α dimer complex with sulfate, [[1qg7]] }}
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'''C-X-C motif chemokine''' (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided to 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.<ref>PMID:16212895</ref><br />
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'''C-X-C motif chemokine''' (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.<ref>PMID:16212895</ref><br />
• '''CXCL2''' or '''MIP-2''' or '''imacrophage inflammatory protein 2''' acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.<br />
• '''CXCL2''' or '''MIP-2''' or '''imacrophage inflammatory protein 2''' acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.<br />

Revision as of 10:18, 20 December 2015

PDB ID 1qg7

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CXCL12α dimer complex with sulfate, 1qg7
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



C-X-C motif chemokine (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.[1]

• CXCL2 or MIP-2 or imacrophage inflammatory protein 2 acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.
• CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.
• CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells.
• CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis.
• CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis.

3D Structures of C-X-C motif chemokine

Updated on 20-December-2015

References

  1. ↑ Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol. 2004 Apr;1(2):95-104. PMID:16212895

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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