Cruzain

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	== Structural highlights ==		== Structural highlights ==
-	Cru catalytic triad is Cys-His-Asn.	+	<scene name='51/517378/Cv/2'>Cru catalytic triad is Cys-His-Asn</scene>.
	</StructureSection>		</StructureSection>

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Revision as of 10:06, 21 December 2015

spinqualitylabelsall models Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry 1me3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Cruzain (Cru) is the major cysteine protease present in Trypanosoma cruzi which is the parasite causing Chagas disease. [1] Relevance Cru inhibitors are being investigated for therapeutic use against Chagas disease. Structural highlights .

3D structures of cruzain

Updated on 21-December-2015

1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ

References

1. ↑ Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15;8(8):831-40. PMID:10997902