Cyclin-dependent kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The kinase <scene name='48/487539/Cv/3'>ATP-binding active site</scene> is located in a <scene name='48/487539/Cv/2'>cleft between the small N-lobe and the large C-lobe</scene>. | + | The kinase <scene name='48/487539/Cv/3'>ATP-binding active site</scene> is located in a <scene name='48/487539/Cv/2'>cleft between the small N-lobe and the large C-lobe</scene>. <scene name='48/487539/Cv/4'>Phosphorylated Thr</scene> near the binding site is required for kinase activity.<ref>PMID:18574471</ref> |
</StructureSection> | </StructureSection> | ||
==3D structures of cyclin-dependent kinase== | ==3D structures of cyclin-dependent kinase== | ||
Revision as of 14:18, 21 December 2015
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3D structures of cyclin-dependent kinase
Updated on 21-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
- ↑ Bettayeb K, Oumata N, Echalier A, Ferandin Y, Endicott JA, Galons H, Meijer L. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. Epub 2008 Jun 23. PMID:18574471 doi:10.1038/onc.2008.191
