Deaminase
From Proteopedia
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| - | <StructureSection load='1p6o' size='350' side='right' caption='Structure of | + | <StructureSection load='1p6o' size='350' side='right' caption='Structure of yeast cytosine deaminase complex with pyridine-based inhibitor, acetate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[1p6o]])' scene=''> |
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== Function == | == Function == | ||
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Mutation in adenine deaminase results in deficiency of the enzyme and is the cause of severe combined immunodeficiency (SCID). | Mutation in adenine deaminase results in deficiency of the enzyme and is the cause of severe combined immunodeficiency (SCID). | ||
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| + | == Structural highlights == | ||
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| + | The active site of cytosine deaminase contains a catalytically active zinc atom.<ref>PMID:12906827</ref> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:46, 22 December 2015
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3D Structures of deaminase
Updated on 22-December-2015
References
- ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
- ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
- ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
- ↑ Ireton GC, Black ME, Stoddard BL. The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003 Aug;11(8):961-72. PMID:12906827
