Death-associated protein kinase
From Proteopedia
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<StructureSection load='1jkl' size='400' side='right' caption='Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry [[1jkl]])' scene=''> | <StructureSection load='1jkl' size='400' side='right' caption='Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry [[1jkl]])' scene=''> | ||
| + | == Function == | ||
| - | '''Death-associated protein kinase''' (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions. DAPK1 is a positive mediator of γ-interferon induced programmed cell death. DAPK2 is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival. DAPK3 or zipper-interacting protein kinase is involved in the regulation of apoptosis. | + | '''Death-associated protein kinase''' (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions. <br /> |
| + | * '''DAPK1''' is a positive mediator of γ-interferon induced programmed cell death. <br /> | ||
| + | * '''DAPK2''' is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival. <br /> | ||
| + | * '''DAPK3''' or zipper-interacting protein kinase is involved in the regulation of apoptosis. <br /> | ||
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| + | == Relevance == | ||
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| + | DAPK1 expression is elevated in brains of Alzheimer Disease patients. | ||
</StructureSection> | </StructureSection> | ||
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**[[2j90]], [[3bhy]], [[3bqr]] - hDAPK catalytic domain + inhibitor<br /> | **[[2j90]], [[3bhy]], [[3bqr]] - hDAPK catalytic domain + inhibitor<br /> | ||
}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:10, 22 December 2015
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3D structures of death-associated protein kinase
Updated on 22-December-2015
