Defensin
From Proteopedia
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| + | <StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | ||
| + | == Function == | ||
| - | '''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients. | + | '''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients.<ref>PMID:11742345</ref> For details on plant DEF see [[Plant defensin]]. |
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| + | == Relevance == | ||
| + | There is increase in α-DEF in chronic inflammations and several cancers. | ||
| + | </StructureSection> | ||
==3D structures of defensin== | ==3D structures of defensin== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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**[[2lr3]] – DEF – barrel medic – NMR<br /> | **[[2lr3]] – DEF – barrel medic – NMR<br /> | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:49, 22 December 2015
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3D structures of defensin
Updated on 22-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
