Dehydroquinase
From Proteopedia
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| - | <StructureSection load='4gui' size='350' side='right' caption='Structure of dehydroquinase type I complex with shikimate and Ni+2 ion (PDB entry [[4gui]])' scene=''> | + | <StructureSection load='4gui' size='350' side='right' caption='Structure of dehydroquinase type I complex with shikimate and Ni<sup>+2</sup> ion (PDB entry [[4gui]])' scene=''> |
| + | == Function == | ||
| - | '''Dehydroquinase''' (DHQD) catalyzes the conversion of 3-hydroquinate to 3- | + | '''Dehydroquinase''' (DHQD) catalyzes the conversion of 3-hydroquinate to 3-hydroshikimate. DHQD is part of the shikimate pathway by which bacteria synthesize the aromatic amino acids. There are 2 types of DHQD found in different organisms. They differ in their sequence and structure. <ref>PMID:12242393</ref> |
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| + | == Relevance == | ||
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| + | Inhibitors of DHQD are potential bacteriocides.<ref>PMID:21410435</ref> | ||
</StructureSection> | </StructureSection> | ||
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**[[2xb8]], [[3n76]], [[3n7a]], [[3n86]], [[3n87]], [[3n8n]], [[2y71]], [[2y76]], [[2y77]], [[4b6o]], [[4b6p]], [[4b6q]], [[4civ]], [[4cix]], [[4ciw]], [[4ciy]], [[4ki7]], [[4kij]], [[4kiu]], [[4kiw]] – MtDHQD + inhibitor<br /> | **[[2xb8]], [[3n76]], [[3n7a]], [[3n86]], [[3n87]], [[3n8n]], [[2y71]], [[2y76]], [[2y77]], [[4b6o]], [[4b6p]], [[4b6q]], [[4civ]], [[4cix]], [[4ciw]], [[4ciy]], [[4ki7]], [[4kij]], [[4kiu]], [[4kiw]] – MtDHQD + inhibitor<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:52, 23 December 2015
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3D structures of dehydroquinase
Updated on 23-December-2015
References
- ↑ Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907
- ↑ Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002
